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Protein complexes mediated by numerous put up-translational modifications (PTMs) play important roles in nearly each facet of biological processes. PTM-mediated protein complexes typically have weak and transient binding properties, which restrict their unbiased profiling especially in complicated biological samples. Here, we developed a plug-and-play chemical proteomic strategy for high-throughput analyis of PTM-mediated protein complexes. You may also design your individual or observe blue-prints, which some individuals love, others hate. However there can also be a center-ground: swing set packages the place you purchase a box with the hardware and customarily the swings included, however select and buy your lumber and greater equipment like the slide individually.

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